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C-Heparin

The raw material for heparin, which used to be extracted from porcine intestinal membranes,
is sourced from cell culture without sacrificing pigs.

The raw material for heparin, which used to be extracted from porcine intestinal membranes, is sourced from cell culture without sacrificing pigs.

Cellweaverse's
Sustainable Heparin
Supply Solution

01What is Heparin?

Heparin is a naturally occurring polysaccharide widely used as an anticoagulant. It prevents blood clotting and reduces the risk of thrombosis, making it essential in various medical fields, including cardiovascular surgery, dialysis, and vascular procedures. Beyond its anticoagulant properties, heparin also exhibits anti-inflammatory and antiviral effects, highlighting its diverse physiological benefits.

02Current Status and Challenges of Heparin Supply

Currently, most of the heparin used worldwide is extracted from the intestinal mucosa of pigs. However, this animal-derived production method presents several significant challenges:

Animal Use Safety Supply Instability
Large-scale slaughter and animal sacrifice are required, raising continuous ethical concerns. Pig-derived heparin carries the risk of contamination by pathogens such as viruses, bacteria, and prions, potentially compromising product safety. Production is concentrated in specific countries, and outbreaks of diseases like African Swine Fever (ASF) threaten supply chain stability, leading to global supply uncertainty.

03Advantages of Cellweavers' Cell-Culture-Based Heparin Production

Cellweaverse has developed innovative technology that mass-produces heparin raw materials by culturing pig mast cells. The cell-culture-based heparin raw material produced by Cellweaverse, known as
C-Heparin (Cultured-Heparin), overcomes the limitations of traditional animal-based production methods and offers the following advantages.

Ethical Production Heparin is produced solely through cell culture without animal slaughter, promoting animal welfare and sustainability.
High Safety Manufacturing in sterile and controlled environments significantly reduces the risk of pathogen contamination.
Stable Supply Continuous and large-scale production ensures a stable supply of heparin to the global market.
Consistent Quality Cell culture technology enables the reliable production of high-purity heparin with consistent quality.

Current Method

  • STEP 01Porcine raise and slaughter
  • STEP 02Isolate intestinal mucosa
  • STEP 03Crude heparin extraction
  • STEP 04Heparin-sodium injection

Cellweaverse’s Solution

  • STEP 01Establishment of porcine mast cell line
  • STEP 02 Mass culture
  • STEP 03C-heparin extraction
  • STEP 04Heparin-sodium injection